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The Emerging Roles of microRNAs in Stem Cell Aging

  1. Author:
    Dietrich, Catharine
    Singh, Manish
    Kumar, Nishant
    Singh, Shree Ram

  2. Author Address

    Stem Cell Regulation and Animal Aging Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA., Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA., Hospitalist Division, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, USA., Stem Cell Regulation and Animal Aging Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA. singhshr@mail.nih.gov.,
    1. Year: 2018
  2. Journal: Advances in experimental medicine and biology
    1. 1056
    2. Pages: 11-26
  4. Type of Article: Article
  1. Abstract:

    Aging is the continuous loss of tissue and organ function over time. MicroRNAs (miRNAs) are thought to play a vital role in this process. miRNAs are endogenous small noncoding RNAs that control the expression of target mRNA. They are involved in many biological processes such as developmental timing, differentiation, cell death, stem cell proliferation and differentiation, immune response, aging and cancer. Accumulating studies in recent years suggest that miRNAs play crucial roles in stem cell division and differentiation. In the present chapter, we present a brief overview of these studies and discuss their contributions toward our understanding of the importance of miRNAs in normal and aged stem cell function in various model systems.

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External Sources

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  2. DOI: 10.1007/978-3-319-74470-4_2
  3. PMID: 29754172
  4. View record in Web of Science®
  5. WOS: 000443958200004

Library Notes

  1. Fiscal Year: FY2017-2018
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