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One-pot synthesis and biodistribution of fluorine-18 labeled serum albumin for vascular imaging

  1. Author:
    Basuli, Falguni
    Zhang, Xiang
    Williams, Mark R.
    Seidel, Jurgen
    Green, Michael V.
    Choyke, Peter L.
    Swenson, Rolf E.
    Jagoda, Elaine M.

  2. Author Address

    NHLBI, Imaging Probe Dev Ctr, NIH, Rockville, MD 20852 USA.NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA.NCI Frederick, SAIC Frederick Inc, Leidos Biomed Res Inc, Frederick, MD 21702 USA.
    1. Year: 2018
    2. Date: JUL-AUG
  2. Journal: NUCLEAR MEDICINE AND BIOLOGY
  3. ELSEVIER SCIENCE INC,
    1. 62-63
    2. Pages: 63-70
  5. Type of Article: Article
  6. ISSN: 0969-8051
  1. Abstract:

    Introduction: Equilibrium single-photon radionuclide imaging methods for assessing cardiac function and the integrity of the vascular system have long been in use for both clinical and research purposes. However, positronemitting blood pool agents that could provide PET equivalents to these (and other) clinical procedures have not yet been adopted despite technical imaging advantages offered by PET. Our goal was to develop a PET blood pool tracer that not only meets necessary in vivo biological requirements but can be produced with an uncomplicated and rapid synthesis method which would facilitate clinical translation. Herein, albumin labeled with fluorine-18 was synthesized using a one-pot method and evaluated in vitro and in vivo in rats.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.nucmedbio.2018.05.004
  3. PMID: 29929114
  4. View record in Web of Science®
  5. WOS: 000440958200007

Library Notes

  1. Fiscal Year: FY2017-2018
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