Skip NavigationSkip to Content
Return Return to Search Results

Human herpesvirus 8 cellular immune responses in homosexual men

  1. Author:
    Strickler, H. D.
    Goedert, J. J.
    Bethke, F. R.
    Trubey, C. M.
    O'Brien, T. R.
    Palefsky, J.
    Whitman, J. E.
    Ablashi, D.
    Zeichner, S.
    Shearer, G. M.

  2. Author Address

    Strickler HD Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med 1300 Morris Pk Ave,Belfer 1308-B Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med Bronx, NY 10461 USA NCI, Natl Inst Hlth Bethesda, MD 20892 USA Applicat Int Corp Frederick, MD USA Adv Biotechnol Inc Columbia, MD USA Univ Calif San Francisco San Francisco, CA 94143 USA
    1. Year: 1999
  2. Journal: Journal of Infectious Diseases
    1. 180
    2. 5
    3. Pages: 1682-1685
  4. Type of Article: Article
  1. Abstract:

    Little is known about cellular immunity to human herpesvirus 8 (HHV-8), the virus associated with Kaposi's sarcoma (KS). T cell proliferative responses to purified HHV-8 were measured in homosexual men, a group with elevated HHV-8 seroprevalence and high risk of KS. None of 20 blood donor controls had T cell responses to HHV-8. Among human immunodeficiency virus (HIV)-negative homosexual men, 8 (42%) of 19 HHV-8 seropositive men responded as did 4 (16%) of 25 HHV-8 seronegative men. Among HIV-positive homosexual men, however, none of 21 HHV-8 seropositives had T cell responses to HHV-8, even though most responded to common recall antigens, and 10 had greater than or equal to 400 CD4 cells/mm(3). The results suggest that HHV-8 T cell proliferative responses are common in HIV-negative homosexual men and that HIV infection may be associated with diminished HHV-8 cellular immunity, possibly before there is substantial depletion of CD4 cells. If correct, this could explain why KS occurs relatively early in HIV infection/AIDS. [References: 15]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel