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A Transplantable Syngeneic Allograft Mouse Model for Nongestational Choriocarcinoma of the Ovary

  1. Author:
    Szabova, Ludmila [ORCID]
    Karim, Baktiar
    Gordon, Melanie
    Lu, Lucy
    Pate, Nathan
    Ohler, Zoe

  2. Author Address

    1 Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research at the National Cancer Institute-Frederick, Frederick, MD, USA., 2 Pathology Histotechnology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research at the National Cancer Institute-Frederick, Frederick, MD, USA., 3 Center for Advanced Preclinical Research, National Cancer Institute-Frederick, Frederick, MD, USA.,
    1. Year: 2019
    2. Date: May
    3. Epub Date: 2019 01 13
  2. Journal: Veterinary pathology
    1. 56
    2. 3
    3. Pages: 399-403
  4. Type of Article: Article
  5. Article Number: 300985818823669
  6. ISSN: 0300-9858
  1. Abstract:

    Nongestational choriocarcinoma is a rare malignancy in humans with poor prognosis. Naturally occurring choriocarcinoma is also rare in laboratory mice, and no genetic mouse model accurately recapitulates the features of this cancer. Here we report development of a genetically engineered mouse (GEM) model with alterations in Brca2, Trp53, and RB that develops ovarian tumors. Most of the ovarian tumors displayed histological characteristics of nongestational choriocarcinoma of the ovary (NGCO) (47%) with abundant syncytiotrophoblasts and cytotrophoblasts, positive immunolabeling for human chorionic gonadotropin, and positive periodic acid-Schiff reaction. The rest of the ovarian tumors were serous epithelial ovarian carcinoma (SEOC) (26%) or mixed tumors consisting of NGCO and SEOC (26%). We further established syngeneic orthotopic mouse models for NGCO by in vivo passaging of GEM tumors. These metastatic models provide a platform for evaluating new treatment strategies in preclinical studies aimed at improving outcomes in choriocarcinoma patients.

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External Sources

  1. View Full Text
  2. DOI: 10.1177/0300985818823669
  3. PMID: 30636537
  4. View record in Web of Science®
  5. WOS: 000465430000008

Library Notes

  1. Fiscal Year: FY2018-2019
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