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Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice

  1. Author:
    Orfi, Erik
    Meszaros, Tamas
    Hennies, Mark
    Fulop, Tamas
    Dezsi, Laszlo
    Nardocci, Alexander
    Rosivall, Laszlo
    Hamar, Peter
    Neun, Barry
    Dobrovolskaia, Marina
    Szebeni, Janos
    Szenasi, Gabor

  2. Author Address

    Semmelweis Univ, Nanomed Res & Educ Ctr, Inst Pathophysiol, 1089 Nagyvarad Ter 4, Budapest, Hungary.SeroScience LCC, Cambridge, MA USA.TECOdevelopment GmbH, Rheinbach, Germany.Semmelweis Univ, Inst Clin Expt Res, Budapest, Hungary.Univ Pecs, Med Sch, Inst Translat Med, Pecs, Hungary.NCI, Nanotechnol Characterizat Lab, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.Univ Miskolc, Fac Hlth, Dept Nanobiotechnol & Regenerat Med, Miskolc, Hungary.Semmelweis Univ, Inst Pathophysiol, Budapest, Hungary.
    1. Year: 2019
    2. Date: Feb 26
    3. Epub Date: 2019 02 26
  2. Journal: International journal of nanomedicine
  3. DOVE MEDICAL PRESS LTD,
    1. 14
    2. Pages: 1563-1573
  5. Type of Article: Article
  6. ISSN: 1178-2013
  1. Abstract:

    Purpose: Undesirable complement (C) activation by nanomedicines can entail an adverse immune reaction known as C activation-related pseudoallergy (CARPA) in sensitive patients. The syndrome includes cardiopulmonary, hemodynamic, and a variety of other physiological changes that have been well described in man, pigs, dogs, and rats. However, the information on CARPA is scarce and ambiguous in mice, a species widely used in preclinical studies. The present study aimed to fill this gap by exploring signs of CARPA in mice following i.v. administration of AmBisome and Abelcet, which are nano-formulations of Amphotericin B with high risk to cause CARPA.

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External Sources

  1. View Full Text
  2. DOI: 10.2147/IJN.S187139
  3. PMID: 30880965
  4. PMCID: PMC6396670
  5. View record in Web of Science®
  6. WOS: 000460050300003

Library Notes

  1. Fiscal Year: FY2018-2019
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