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Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

  1. Author:
    Crowell, Trevor A.
    Colby, Donn J.
    Pinyakorn, Suteeraporn
    Sacdalan, Carlo
    Pagliuzza, Amelie
    Intasan, Jintana
    Benjapornpong, Khunthalee
    Tangnaree, Kamonkan
    Chomchey, Nitiya
    Kroon, Eugene
    de Souza, Mark S.
    Tovanabutra, Sodsai
    Rolland, Morgane
    Eller, Michael A.
    Paquin-Proulx, Dominic
    Bolton, Diane L.
    Tokarev, Andrey
    Thomas, Rasmi
    Takata, Hiroshi
    Trautmann, Lydie
    Krebs, Shelly J.
    Modjarrad, Kayvon
    McDermott, Adrian B.
    Bailer, Robert T.
    Doria-Rose, Nicole
    Patel, Bijal
    Gorelick,Robert
    Fullmer,Brandie
    Schuetz, Alexandra
    Grandin, Pornsuk V.
    O'Connell, Robert J.
    Ledgerwood, Julie E.
    Graham, Barney S.
    Tressler, Randall
    Mascola, John R.
    Chomont, Nicolas
    Michael, Nelson L.
    Robb, Merlin L.
    Phanuphak, Nittaya
    Ananworanich, Jintanat
    Ake, Julie
    Akapirat, Siriwat
    Bose, Meera
    Cale, Evan
    Chan, Phillip
    Chanthaburanun, Sararut
    Churikanont, Nampueng
    Dawson, Peter
    Dumrongpisutikul, Netsiri
    Getchalarat, Saowanit
    Jongrakthaitae, Surat
    Jongsakul, Krisada
    Lerdlum, Sukalaya
    Manasnayakorn, Sopark
    McCullough, Corinne
    Milazzo, Mark
    Nuntapinit, Bessara
    Om, Kier
    Ouellette, Madelaine
    Phanuphak, Praphan
    Sanders-Buell, Eric
    Sangnoi, Nongluck
    Shangguan, Shida
    Sirivichayakul, Sunee
    Tragonlugsana, Nipattra
    Trichavaroj, Rapee
    Ubolyam, Sasiwimol
    Vasan, Sandhya
    Wattanaboonyongcharoen, Phandee
    Yamchuenpong, Thipvadee

  2. Author Address

    Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.Univ Montreal, CHUM, Ctr Rech, Montreal, PQ, Canada.Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada.NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA.Armed Forces Res Inst Med Sci, Bangkok, Thailand.Univ Amsterdam, Dept Global Hlth, Amsterdam, Netherlands.
    1. Year: 2019
    2. Date: May
    3. Epub Date: 2019 04 15
  2. Journal: The lancet. HIV
  3. ELSEVIER INC,
    1. 6
    2. 5
    3. Pages: E297-E306
  5. Type of Article: Article
  6. ISSN: 2352-3018
  1. Abstract:

    Background HIV-1-specific broadly neutralising antibodies such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells. We investigated whether VRC01 could promote sustained viral control off antiretroviral therapy (ART) in adults who initiated ART during acute HIV infection.

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External Sources

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  2. DOI: 10.1016/S2352-3018(19)30053-0
  3. PMID: 31000477
  4. View record in Web of Science®
  5. WOS: 000466790400011

Library Notes

  1. Fiscal Year: FY2018-2019
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