Skip NavigationSkip to Content
Return Return to Search Results

Identification of rare HIV-1-infected patients with extreme CD4(+) T cell decline despite ART-mediated viral suppression

  1. Author:
    Lisco, Andrea
    Wong, Chun-Shu
    Lage, Silvia Lucena
    Levy, Itzchak
    Brophy, Jason
    Lennox, Jeffrey
    Manion, Maura
    Anderson, Megan
    Mejia, Yolanda
    Grivas, Christopher
    Mystakelis, Harry
    Burbelo, Peter D.
    Perez-Diez, Ainhoa
    Rupert,Adam
    Martens, Craig A.
    Anzick, Sarah L.
    Morse, Caryn
    Chan, Shanna
    Deleage,Claire
    Sereti, Irini

  2. Author Address

    NIAID, Lab Immunoregulat, HIV Pathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Tel Hashomer & Sackler Med Sch, Sheba Med Ctr, Tel Aviv, Israel.Childrens Hosp Eastern Ontario, Ottawa, ON, Canada.Emory Univ, Grady Mem Hosp, Atlanta, GA 30322 USA.Natl Inst Dent & Craniofacial Res, Dent Clin Res Core, NIH, Bethesda, MD USA.Leidos Biomed Res, AIDS Monitoring Lab, Frederick, MD USA.NIAID, Rocky Mt Lab, Genom Unit, NIH, Hamilton, MT 59840 USA.Winnipeg Reg Hlth Author, Winnipeg, MB, Canada.Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Tissue Anal Core, Frederick, MD USA.
    1. Year: 2019
    2. Date: APR 18
    3. Epub Date: 2019 04 18
  2. Journal: JCI INSIGHT
  3. AMER SOC CLINICAL INVESTIGATION INC,
    1. 4
    2. 8
    3. Pages: pii: 127113
  5. Type of Article: Article
  6. Article Number: e127113
  7. ISSN: 2379-3708
  1. Abstract:

    BACKGROUND. The goal of antiretroviral therapy (ART) is to suppress HIV-1 replication and reconstitute CD4(+) T cells. Here, we report on HIV-infected individuals who had a paradoxical decline in CD4(+ )T cells despite ART-mediated suppression of plasma HIV-1 load (pVL). We defined such an immunological outcome as extreme immune decline (EXID).

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1172/jci.insight.127113
  3. PMID: 30996137
  4. View record in Web of Science®
  5. WOS: 000465334200022

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel