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Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis

  1. Author:
    Yan, Lijun
    Majerciak,Vladimir
    Zheng,Zhi-Ming
    Lan, Ke

  2. Author Address

    Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China.NCI, NIH, Frederick, MD 21702 USA.
    1. Year: 2019
    2. Date: APR
    3. Epub Date: 2019 04 25
  2. Journal: Virologica Sinica
  3. SPRINGER,
    1. 34
    2. 2
    3. Pages: 135-161
  5. Type of Article: Review
  6. ISSN: 1674-0769
  1. Abstract:

    Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8 (HHV-8), is etiologically linked to the development of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.

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External Sources

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  2. DOI: 10.1007/s12250-019-00114-3
  3. PMID: 31025296
  4. View record in Web of Science®
  5. WOS: 000468118700003

Library Notes

  1. Fiscal Year: FY2018-2019
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