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The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

  1. Author:
    Bender, Alexandra M
    Simonetti, Francesco R
    Kumar, Mithra R
    Fray, Emily J
    Bruner, Katherine M
    Timmons, Andrew E
    Tai, Katherine Y
    Jenike, Katharine M
    Antar, Annukka A R
    Liu, Po-Ting
    Ho, Ya-Chi
    Raugi, Dana N
    Seydi, Moussa
    Gottlieb, Geoffrey S
    Okoye, Afam A
    Del Prete,Greg
    Picker, Louis J
    Mankowski, Joseph L
    Lifson,Jeffrey
    Siliciano, Janet D
    Laird, Greg M
    Barouch, Dan H
    Clements, Janice E
    Siliciano, Robert F

  2. Author Address

    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Department of Medicine & Center of Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA, USA., Service de Maladies Infectieuses et Tropicales, CHNU-Fann, Dakar, Senegal., Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD, USA., Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Accelevir Diagnostics, Baltimore, MD, USA., Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA. Electronic address: rsiliciano@jhmi.edu.,
    1. Year: 2019
    2. Date: Jul 10
  2. Journal: Cell host & microbe
    1. 26
    2. 1
    3. Pages: 73-85.e4
  4. Type of Article: Article
  5. ISSN: 1931-3128
  1. Abstract:

    Evaluation of HIV cure strategies is complicated by defective proviruses that persist in ART-treated patients but are irrelevant to cure. Non-human primates (NHP) are essential for testing cure strategies. However, the persisting proviral landscape in ART-treated NHPs is uncharacterized. Here, we describe viral genomes persisting in ART-treated, simian immunodeficiency virus (SIV)-infected NHPs, simian-human immunodeficiency virus (SHIV)-infected NHPs, and humans infected with HIV-2, an SIV-related virus. The landscapes of persisting SIV, SHIV, and HIV-2 genomes are also dominated by defective sequences. However, there was a significantly higher fraction of intact SIV proviral genomes compared to ART-treated HIV-1 or HIV-2 infected humans. Compared to humans with HIV-1, SIV-infected NHPs had more hypermutated genomes, a relative paucity of clonal SIV sequences, and a lower frequency of deleted genomes. Finally, we report an assay for measuring intact SIV genomes which may have value in cure research. Copyright © 2019 Elsevier Inc. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.chom.2019.06.005
  3. PMID: 31295427
  4. View record in Web of Science®
  5. WOS: 000474689300011
  6. PII : S1931-3128(19)30294-X

Library Notes

  1. Fiscal Year: FY2018-2019
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