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PREVAIL I Cluster Vaccination Study With rVSV Delta G-ZEBOV-GP as Part of a Public Health Response in Liberia

  1. Author:
    Bolay, Fatorma K.
    Grandits, Greg
    Lane, H. Clifford
    Kennedy, Stephen B.
    Johnson, Melvin P.
    Fallah, Mosoka P.
    Wilson, Barthalomew
    Njoh,Wissedi
    McNay, Laura A.
    Hensley, Lisa E.
    Higgs, Elizabeth S.

  2. Author Address

    Natl Publ Hlth Inst Liberia, Monrovia, Liberia.Univ Minnesota, Div Biostat, Minneapolis, MN USA.NIAID, Div Clin Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Liberia Coll Phys & Surg, Monrovia, Liberia.PREVAIL, Monrovia, Liberia.Leidos Biomed Res Inc, Frederick, MD USA.
    1. Year: 2019
    2. Date: May 15
    3. Epub Date: 2018 12 17
  2. Journal: JOURNAL OF INFECTIOUS DISEASES
  3. OXFORD UNIV PRESS INC,
    1. 219
    2. 10
    3. Pages: 1634-1641
  5. Type of Article: Article
  6. ISSN: 0022-1899
  1. Abstract:

    Objective. In November 2015, a 15-year-old boy received a diagnosis of Ebola virus disease (EVD) at the John F. Kennedy Medical Center in Monrovia, Liberia. Two additional family members received a diagnosis of EVD. The protocol for a phase 2 placebo-controlled trial of 2 Ebola vaccines was amended and approved; in 4 days, a single-arm cluster vaccination trial using the Merck rVSV Delta G-ZEBOV-GP vaccine was initiated. Here, we evaluate the safety and immunogenicity of the vaccine and discuss challenges for its implementation in a small Ebola outbreak.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiy698
  3. PMID: 30561672
  4. PMCID: PMC6562162
  5. View record in Web of Science®
  6. WOS: 000473776700015

Library Notes

  1. Fiscal Year: FY2018-2019
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