Skip NavigationSkip to Content
Return Return to Search Results

Intestinal non-canonical NF kappa B signaling shapes the local and systemic immune response

  1. Author:
    Ramakrishnan, Sadeesh K.
    Zhang, Huabing
    Ma, Xiaoya
    Jung, Inkyung
    Schwartz, Andrew J.
    Triner, Daniel
    Devenport, Samantha N.
    Das, Nupur K.
    Xue, Xiang
    Zeng, Melody Y.
    Hu,Yinling
    Mortensen, Richard M.
    Greenson, Joel K.
    Cascalho, Marilia
    Wobus, Christiane E.
    Colacino, Justin A.
    Nunez, Gabriel
    Rui, Liangyou
    Shah, Yatrik M.

  2. Author Address

    Univ Pittsburgh, Dept Med, 930 Scaife Hall, Pittsburgh, PA 15261 USA.Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA.Univ Michigan, Internal Med, Ann Arbor, MI 48109 USA.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Ft Detrick, MD 21702 USA.Univ Michigan, Transplantat Biol, Ann Arbor, MI 48109 USA.Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA.Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA.Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.Univ Michigan, Dept Nutr Sci, Ann Arbor, MI 48109 USA.Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA.
    1. Year: 2019
    2. Date: Feb 8
    3. Epub Date: 2019 02 08
  2. Journal: Nature communications
  3. NATURE PUBLISHING GROUP,
    1. 10
    2. 1
  5. Type of Article: Article
  6. Article Number: 660
  7. ISSN: 2041-1723
  1. Abstract:

    Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still unclear. Here we show that epithelial non-canonical NFkB signaling mediated by NFkB-inducing kinase (NIK) is highly active in intestinal lymphoid follicles, and is required for M-cell maintenance. Intestinal NIK signaling modulates M-cell differentiation and elicits both local and systemic IL-17A and IgA production. Importantly, intestinal NIK signaling is active in mouse models of colitis and patients with inflammatory bowel diseases; meanwhile, constitutive NIK signaling increases the susceptibility to inflammatory injury by inducing ectopic M-cell differentiation and a chronic increase of IL-17A. Our work thus defines an important function of non-canonical NFkB and M-cells in immune homeostasis, inflammation and polymicrobial sepsis.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/s41467-019-08581-8
  3. PMID: 30737385
  4. PMCID: PMC6368617
  5. View record in Web of Science®
  6. WOS: 000458175300009

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel