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IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

  1. Author:
    Conlon, Kevin C.
    Potter, E. Lake
    Pittaluga, Stefania
    Lee, Chyi-Chia Richard
    Miljkovic, Milos D.
    Fleisher, Thomas A.
    Dubois, Sigrid
    Bryant, Bonita R.
    Petrus, Michael
    Perera, Liyanage P.
    Hsu, Jennifer
    Figg, William D.
    Peer, Cody J.
    Shih, Joanna H.
    Yovandich,Jason
    Creekmore,Stephen
    Roederer, Mario
    Waldmann, Thomas A.

  2. Author Address

    NCI, Lymphoid Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NIAID, Immunotechnol Sect, Vaccine Res Ctr, NIH, Bethesda, MD USA.NCI, Lab Pathol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NIH, NIH Clin Ctr, Dept Lab Med, Bldg 10, Bethesda, MD 20892 USA.NCI, Genitourinary Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NCI, Biometr Res Program, Div Canc Treatment & Diag, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.NCI, Biol Resources Branch, Div Canc Treatment & Diag, Dev Therapeut Program,NIH, Frederick, MD 21701 USA.
    1. Year: 2019
    2. Date: Aug 15
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 25
    2. 16
    3. Pages: 4945-4954
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: The first-in-human clinical trial with human bolus intravenous infusion IL15 (rhIL15) was limited by treatment-associated toxicity. Here, we report toxicity, immunomodulation, and clinical activity of rhIL15 administered as a 10-day continuous intravenous infusion (CIV) to patients with cancers in a phase I trial.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-18-3468
  3. PMID: 31142503
  4. PMCID: PMC6697593
  5. View record in Web of Science®
  6. WOS: 000481912400012

Library Notes

  1. Fiscal Year: FY2018-2019
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