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Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides

  1. Author:
    Yadav, Yogesh
    Sharma, Deepti
    Kaushik, Kumar
    Kumar, Vineet
    Jha, Amitabh
    Prasad, Ashok K
    Len, Christophe
    Malhotra, Sanjay V
    Wengel, Jesper
    Parmar, Virinder S

  2. Author Address

    Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India. yogeshyadav77@gmail.com., Medicinal Chemistry Laboratory, Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6, Canada. yogeshyadav77@gmail.com., SUN Pharmaceuticals R&D, Gurgaon, Sarhaul, Sector-18, Haryana-122 015, India. yogeshyadav77@gmail.com., Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India. deeptichem@rediffmail.com., Sri Venkateswara College, Benito Juarez Road, Dhaula Kuan, University of Delhi, Delhi 110 021, India. deeptichem@rediffmail.com., Department of Chemistry and Environmental Science, Medgar Evers College, The City University of New York, 1638 Bedford Avenue, Brooklyn, NY 11225, USA. kumar.kaushik.drdo@gmail.com., Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India. iamvineet@gmail.com., Laboratory of Synthetic Chemistry, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 2170, USA. iamvineet@gmail.com., Department of Radiation Oncology, Stanford University, 1050A Arastradero Road, A252, Palo Alto, CA 94304, USA. iamvineet@gmail.com., Medicinal Chemistry Laboratory, Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6, Canada. amitabh.jha@acadiau.ca., Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India. ashokenzyme@gmail.com., Chimie ParisTech, PSL University, CNRS Institute of Chemistry for Life and Health Sciences-i-CLeHS, 11 rue Pierre et Marie Curie, F-75005 Paris, France. christophe.len@chimieparistech.psl.eu., Laboratory of Synthetic Chemistry, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 2170, USA. smalhotra@stanford.edu., Department of Radiation Oncology, Stanford University, 1050A Arastradero Road, A252, Palo Alto, CA 94304, USA. smalhotra@stanford.edu., Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark. jwe@sdu.dk., Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India. vparmar@mec.cuny.edu., Department of Chemistry and Environmental Science, Medgar Evers College, The City University of New York, 1638 Bedford Avenue, Brooklyn, NY 11225, USA. vparmar@mec.cuny.edu., Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark. vparmar@mec.cuny.edu.,
    1. Year: 2019
    2. Date: Nov
    3. Epub Date: 2019 10 30
  2. Journal: Molecules (Basel, Switzerland)
    1. 24
    2. 21
    3. Pages: pii: E3922
  4. Type of Article: Article
  5. Article Number: 3922
  6. ISSN: 1420-3049
  1. Abstract:

    The synthesis of novel pyrazolylnucleosides 3a-e, 4a-e, 5a-e, and 6a-e are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5a-e and 6a-e were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI50 9.3 µM) and breast cancer cell line HS 578T (GI50 3.0 µM).

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules24213922
  3. PMID: 31671703
  4. View record in Web of Science®
  5. WOS: 000498055500111
  6. PII : molecules24213922

Library Notes

  1. Fiscal Year: FY2019-2020
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