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A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor

  1. Author:
    Glod, John
    Arnaldez, Fernanda I.
    Wiener, Lori
    Spencer, Melissa
    Killian, J. Keith
    Meltzer, Paul
    Dombi, Eva
    Derse-Anthony, Claudia
    Derdak, Joanne
    Srinivasan, Ramaprasad
    Linehan, W. Marston
    Miettinen, Markku
    Steinberg, Seth M.
    Helman, Lee
    Widemann, Brigitte C.

  2. Author Address

    NCI, Pediat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.NCI, Genet Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NCI, Clin Res Directorate, Frederick Natl Lab Canc Res, Bethesda, MD 20892 USA.NCI, Urol Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NCI, Lab Pathol, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA.NCI, Biostat & Data Management Sect, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
    1. Year: 2019
    2. Date: Nov 1
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 25
    2. Pages: 6302-6308
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: Gastrointestinal stromal tumors ( GIST) are resistant to cytotoxic chemotherapy and radiotherapy. Most GIST in children are wild-type for KIT and PDGFRA (WT GIST) and deficient in expression of succinate dehydrogenase (dSDH GIST). We tested the activity of vandetanib, an oral small-molecule inhibitor of VEGFR2, EGFR, and RET, in patients with dSDH GIST.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-19-0986
  3. PMID: 31439578
  4. PMCID: PMC6825553
  5. View record in Web of Science®
  6. WOS: 000494399300005

Library Notes

  1. Fiscal Year: FY2019-2020
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