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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

  1. Author:
    Wong, Jason Y. Y.
    Zhang, Han
    Hsiung, Chao A.
    Shiraishi, Kouya
    Yu, Kai
    Matsuo, Keitaro
    Wong, Maria Pik
    Hong, Yun-Chul
    Wang, Jiucun
    Seow, Wei Jie
    Wang, Zhaoming
    Song, Minsun
    Kim, Hee Nam
    Chang, I-Shou
    Chatterjee, Nilanjan
    Hu, Wei
    Wu, Chen
    Mitsudomi, Tetsuya
    Zheng, Wei
    Kim, Jin Hee
    Seow, Adeline
    Caporaso, Neil E.
    Shin, Min-Ho
    Chung, Lap Ping
    An, She-Juan
    Wang, Ping
    Yang, Yang
    Zheng, Hong
    Yatabe, Yasushi
    Zhang, Xu-Chao
    Kim, Young Tae
    Cai, Qiuyin
    Yin, Zhihua
    Kim, Young-Chul
    Bassig, Bryan A.
    Chang, Jiang
    Ho, James Chung N.
    Ji, Bu-Tian
    Daigo, Yataro
    Ito, Hidemi
    Momozawa, Yukihide
    Ashikawa, Kyota
    Kamatani, Yoichiro
    Honda, Takayuki
    Hosgood, H. Dean
    Sakamoto, Hiromi
    Kunitoh, Hideo
    Tsuta, Koji
    Watanabe, Shun-Ichi
    Kubo, Michiaki
    Miyagi, Yohei
    Nakayama, Haruhiko
    Matsumoto, Shingo
    Tsuboi, Masahiro
    Goto, Koichi
    Shi, Jianxin
    Song, Lei
    Hua, Xing
    Takahashi, Atsushi
    Goto, Akiteru
    Minamiya, Yoshihiro
    Shimizu, Kimihiro
    Tanaka, Kazumi
    Wei, Fusheng
    Matsuda, Fumihiko
    Su, Jian
    Kim, Yeul Hong
    Oh, In-Jae
    Song, Fengju
    Su, Wu-Chou
    Chen, Yu-Min
    Chang, Gee-Chen
    Chen, Kuan-Yu
    Huang, Ming-Shyan
    Chien, Li-Hsin
    Xiang, Yong-Bing
    Park, Jae Yong
    Kweon, Sun-Seog
    Chen, Chien-Jen
    Lee, Kyoung-Mu
    Blechter, Batel
    Li, Haixin
    Gao, Yu-Tang
    Qian, Biyun
    Lu, Daru
    Liu, Jianjun
    Jeon, Hyo-Sung
    Hsiao, Chin-Fu
    Sung, Jae Sook
    Tsai, Ying-Huang
    Jung, Yoo Jin
    Guo, Huan
    Hu, Zhibin
    Wang, Wen-Chang
    Chung,Charles
    Burdett,Laurie
    Yeager,Meredith
    Hutchinson,Amy
    Berndt,Sonja
    Wu, Wei
    Pang, Herbert
    Li, Yuqing
    Choi, Jin Eun
    Park, Kyong Hwa
    Sung, Sook Whan
    Liu, Li
    Kang, C. H.
    Zhu, Meng
    Chen, Chung-Hsing
    Yang, Tsung-Ying
    Xu, Jun
    Guan, Peng
    Tan, Wen
    Wang, Chih-Liang
    Hsin, Michael
    Sit, Ko-Yung
    Ho, James
    Chen, Ying
    Choi, Yi Young
    Hung, Jen-Yu
    Kim, Jun Suk
    Il Yoon, Ho
    Lin, Chien-Chung
    Park, In Kyu
    Xu, Ping
    Wang, Yuzhuo
    He, Qincheng
    Perng, Reury-Perng
    Chen, Chih-Yi
    Vermeulen, Roel
    Wu, Junjie
    Lim, Wei-Yen
    Chen, Kun-Chieh
    Li, Yao-Jen
    Li, Jihua
    Chen, Hongyan
    Yu, Chong-Jen
    Jin, Li
    Chen, Tzu-Yu
    Jiang, Shih-Sheng
    Liu, Jie
    Yamaji, Taiki
    Hicks,Belynda
    Wyatt,Kathleen
    Li,Shengchao
    Dai, Juncheng
    Ma, Hongxia
    Jin, Guangfu
    Song, Bao
    Wang, Zhehai
    Cheng, Sensen
    Li, Xuelian
    Ren, Yangwu
    Cui, Ping
    Iwasaki, Motoki
    Shimazu, Taichi
    Tsugane, Shoichiro
    Zhu, Junjie
    Yang, Kaiyun
    Jiang, Gening
    Fei, Ke
    Wu, Guoping
    Lin, Hsien-Chin
    Chen, Hui-Ling
    Fang, Yao-Huei
    Tsai, Fang-Yu
    Hsieh, Wan-Shan
    Yu, Jinming
    Stevens, Victoria L.
    Laird-Offringa, Ite A.
    Marconett, Crystal N.
    Rieswijk, Linda
    Chao, Ann
    Yang, Pan-Chyr
    Shu, Xiao-Ou
    Wu, Tangchun
    Wu, Y. L.
    Lin, Dongxin
    Chen, Kexin
    Zhou, Baosen
    Huang, Yun-Chao
    Kohno, Takashi
    Shen, Hongbing
    Chanock, Stephen J.
    Rothman, Nathaniel
    Lan, Qing

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan.Natl Canc Ctr, Div Genome Biol, Res Inst, Tokyo, Japan.Aichi Canc Ctr, Div Canc Epidemiol & Prevent, Res Inst, Nagoya, Aichi, Japan.Nagoya Univ, Dept Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Peoples R China.Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.Leidos Biomed Res Inc, Canc Genom Res Lab, Gaithersburg, MD USA.St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA.Sookmyung Womens Univ, Dept Stat, Seoul, South Korea.Chonnam Natl Univ, Dept Prevent Med, Med Sch, Gwangju, South Korea.Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China.Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China.Kinki Univ, Div Thorac Surg, Sch Med, Sayama, Osaka, Japan.Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.Vanderbilt Ingram Canc Ctr, Nashville, TN USA.Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul, South Korea.Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangdong Lung Canc Inst, Guangzhou, Peoples R China.Guangdong Acad Med Sci, Guangdong Gen Hosp, Canc Ctr, Guangzhou, Peoples R China.Tianjin Med Univ, Natl Clin Res Ctr Canc, Dept Radiotherapy, Key Lab Canc Prevent & Therapy,Canc Inst & Hosp, Tianjin, Peoples R China.Shanghai Pulm Hosp, Shanghai, Peoples R China.Tianjin Med Univ, Dept Epidemiol & Biostat, Canc Inst & Hosp, Tianjin, Peoples R China.Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Cent Hosp, Nagoya, Aichi, Japan.Seoul Natl Univ, Canc Res Inst, Dept Thorac & Cardiovasc Surg, Coll Med, Seoul, South Korea.China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang, Peoples R China.Chonnam Natl Univ, Hwasun Eup, Lung & Esophageal Canc Clin, Hwasun Eup, South Korea.Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea.Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam Rd, Hong Kong, Peoples R China.Shiga Univ Med Sci, Dept Med Oncol, Otsu, Shiga, Japan.Shiga Univ Med Sci, Canc Ctr, Otsu, Shiga, Japan.Univ Tokyo, Res Hosp, Ctr Antibody & Vaccine Therapy, Inst Med Sci, Tokyo, Japan.Aichi Canc Ctr, Div Canc Informat & Control, Res Inst, Nagoya, Aichi, Japan.Nagoya Univ, Dept Descript Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan.RIKEN, Lab Genotyping Dev, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan.RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.Natl Canc Ctr, Div Genet, Res Inst, Tokyo, Japan.Japanese Red Cross Med Ctr, Dept Med Oncol, Tokyo, Japan.Kansai Med Univ, Dept Pathol & Lab Med, Osaka, Japan.Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan.Kanagawa Canc Ctr, Mol Pathol & Genet Div, Res Inst, Yokohama, Kanagawa, Japan.Kanagawa Canc Ctr, Dept Thorac Surg, Yokohama, Kanagawa, Japan.Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr EPOC, Div Translat Res, Chiba, Japan.Natl Canc Ctr Hosp East, Dept Thorac Surg, Chiba, Japan.Natl Canc Ctr Hosp East, Dept Thorac Oncol, Chiba, Japan.Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Genom Med, Osaka, Japan.Akita Univ, Grad Sch Med, Dept Cellular & Organ Pathol, Akita, Japan.Akita Univ, Grad Sch Med, Dept Thorac Surg, Akita, Japan.Gunma Univ Hosp, Dept Integrat, Ctr Gen Surg, Gunma, Japan.China Natl Environm Monitoring Ctr, Beijing, Peoples R China.Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan.Korea Univ, Coll Med, Dept Internal Med, Div Oncol Hematol,Anam Hosp, Seoul, South Korea.Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan.Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan.Natl Yang Ming Univ, Fac Med, Sch Med, Taipei, Taiwan.Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan.Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.Natl Taiwan Univ, Coll Med, Taipei, Taiwan.I Shou Univ, E Da Canc Hosp, Sch Med, Dept Internal Med, Kaohsiung, Taiwan.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst,Sch Med, State Key Lab Oncogene & Related Genes, Shanghai, Peoples R China.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Dept Epidemiol,Sch Med, Shanghai, Peoples R China.Kyungpook Natl Univ, Lung Canc Ctr, Med Ctr, Daegu, South Korea.Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun Hosp, Hwasun Eup, South Korea.Acad Sinica, Genom Res Ctr, Taipei, Taiwan.Korea Natl Open Univ, Dept Environm Hlth, Seoul, South Korea.Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China.Genome Inst Singapore, Dept Human Genet, Singapore, Singapore.Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China.Kyungpook Natl Univ, Canc Res Ctr, Med Ctr, Daegu, South Korea.Chiayi Chang Gung Mem Hosp, Div Pulm & Crit Care Med, Chiayi, Taiwan.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Peoples R China.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan, Peoples R China.Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China.Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei, Taiwan.Univ Hong Kong, Sch BioMed Sci, Hong Kong, Peoples R China.Canc Prevent Inst Calif, Fremont, CA USA.Catholic Univ Korea, Seoul St Marys Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.Huazhong Univ Sci & Technol, Union Hosp, Canc Ctr, Dept Oncol, Wuhan, Peoples R China.Univ Hong Kong, Li Ka Shing LKS Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China.Univ Liaoning Prov, Key Lab Canc Etiol & Intervent, Shenyang, Peoples R China.Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan.Univ Hong Kong, Queen Mary Hosp, Dept Cardiothorac Surg, Hong Kong, Peoples R China.Univ Hong Kong, Dept Med, Hong Kong, Peoples R China.Korea Univ, Coll Med, Dept Internal Med, Div Med Oncol,Guro Hosp, Seoul, South Korea.Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea.Wuhan Iron & Steel Corp, Dept Oncol, Staff Worker Hosp, Wuhan, Peoples R China.Taipei Vet Gen Hosp, Chest Dept, Taipei, Taiwan.Chung Shan Med Univ, Inst Med, Taichung, Taiwan.Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg, Taichung, Taiwan.Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands.Agcy Integrated Care, Singapore, Singapore.Qujing Ctr Dis Control & Prevent, Sanjiangdadao, Qujing, Peoples R China.Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan.Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Oncol, Jinan, Peoples R China.Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan.Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Thorac Surg,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China.Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.Univ Southern Calif, Norris Comprehens Canc Ctr, Keck Sch Med, Dept Surg,Dept Biochem & Mol Med, Los Angeles, CA 90007 USA.Univ Calif Berkeley, Sch Publ Hlth, Environm Hlth Sci Div, Berkeley, CA 94720 USA.NCI, Ctr Global Hlth, Bethesda, MD 20892 USA.Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China.
    1. Year: 2020
    2. Date: MAR
  2. Journal: GENOMICS
  3. ACADEMIC PRESS INC ELSEVIER SCIENCE,
    1. 112
    2. Pages: 1223-1232
  5. Type of Article: Article
  6. ISSN: 0888-7543
  1. Abstract:

    We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.ygeno.2019.07.008
  3. PMID: 31306748
  4. PMCID: PMC6954985
  5. View record in Web of Science®
  6. WOS: 000514071600020

Library Notes

  1. Fiscal Year: FY2019-2020
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