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Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells

  1. Author:
    Tosun, Fatma
    Mihoglugil, Feyyaz
    Beutler,John [ORCID]
    Eroglu Özkan, Esra [ORCID]
    Miski, Mahmut [ORCID]

  2. Author Address

    School of Pharmacy, Department of Pharmacognosy, Istanbul Medipol University, 34810 Istanbul, Turkey., Faculty of Pharmacy, Department of Pharmacognosy, Cyprus International University, 99258 Nicosia, Northern Cyprus., Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Faculty of Pharmacy, Department of Pharmacognosy, Istanbul University, 34116 Istanbul, Turkey.,
    1. Year: 2020
    2. Date: Jul 03
    3. Epub Date: 2020 07 03
  2. Journal: Molecules (Basel, Switzerland)
    1. 25
    2. 13
  4. Type of Article: Article
  5. Article Number: E3040
  6. ISSN: 1420-3049
  1. Abstract:

    Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4 39;-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules25133040
  3. PMID: 32635247
  4. View record in Web of Science®
  5. WOS: 000560014200001
  6. PII : molecules25133040

Library Notes

  1. Fiscal Year: FY2019-2020
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