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Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection

  1. Author:
    Cai, Catherine W
    Pinyakorn, Suteeraporn
    Kroon, Eugène
    de Souza, Mark
    Colby, Donn J
    Pankam, Tippawan
    Pattanachaiwit, Supanit
    Ubolyam, Sasiwimol
    Rupert,Adam
    Lallemand,Perrine
    Dewar,Robin
    Highbarger,Helene
    Ananworanich, Jintanat
    Vasan, Sandhya
    Sereti, Irini [ORCID]

  2. Author Address

    HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., US Military Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., South East Asia Research Collaboration in HIV (SEARCH), Thai Red Cross AIDS Research Centre, Bangkok, Thailand., The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand., Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.,
    1. Year: 2020
    2. Date: Sep
    3. Epub Date: 2020 08 26
  2. Journal: Open Forum Infectious Diseases
    1. 7
    2. 9
    3. Pages: pii: ofaa383
  4. Type of Article: Article
  5. Article Number: ofaa383
  6. ISSN: 2328-8957
  1. Abstract:

    Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic inflammation in early treated PWH. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/ofid/ofaa383
  3. PMID: 33005700
  4. PMCID: PMC7519777
  5. View record in Web of Science®
  6. WOS: 000593127000043
  7. PII : ofaa383

Library Notes

  1. Fiscal Year: FY2020-2021
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