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Caenorhabditis elegans contains a third Polo-like kinase gene

  1. Author:
    Chase, D.
    Golden, A.
    Heidecker, G.
    Ferris, D. K.

  2. Author Address

    NCI, NIA, FCRF, Frederick, MD 21702 USA. NCI, NIA, FCRF, Frederick, MD 21702 USA. NCI, FCRF, SAIC, Frederick, MD 21702 USA. Yale Univ, Sch Med, New Haven, CT 06520 USA. NIDDKD, LBG, Bethesda, MD 20892 USA.
    1. Year: 2000
  2. Journal: DNA Sequence
    1. 11
    2. 3-4
    3. Pages: 327-334
  4. Type of Article: Article
  1. Abstract:

    The Polo family of serine/ threonine kinases have been implicated in cell cycle control in a number of diverse organisms. Their localization and biochemical activity suggest that they play an important role in centrosome maturation, G2- to-M phase progression, the promotion of anaphase, and cytokinesis. The Polo family of kinases is distinct from other serine/threonine kinases in that they all contain a polo-box sequence motif in their non-catalytic C-terminal domain. Recently, it was reported that two Polo-related kinases, Plc1 and Plc2, are present in C. elegans. Plc2 has diverged from Plc1 with poor homology within the polo-box sequence and only had 40% amino acid identity with Plc1. We report here the full- length cDNA sequence of another Polo-related kinase from C. elegans. The predicted protein product has greater than 70% amino acid identity with PLK-1/Plc1, and has a highly conserved polo-box domain.

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