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The Polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans

  1. Author:
    Chase, D.
    Serafinas, C.
    Ashcroft, N.
    Kosinski, M.
    Longo, D.
    Ferris, D. K.
    Golden, A.

  2. Author Address

    NCI, Frederick Canc Res Facil, SAIC, Frederick, MD 21701 USA. NCI, Frederick Canc Res Facil, SAIC, Frederick, MD 21701 USA. NCI, NIA, FCRF, Frederick, MD 21702 USA. NCI, Lab Leukocyte BIol, FCRF, Frederick, MD 21702 USA. NCI, Dev Signal Transduct Grp, Gene Regulat & Chromosome Biol Lab, FCRF, Frederick, MD 21702 USA. NIA, Baltimore, MD 21224 USA.
    1. Year: 2000
  2. Journal: Genesis
    1. 26
    2. 1
    3. Pages: 26-41
  4. Type of Article: Article
  1. Abstract:

    The Polo-like kinases are key regulatory molecules required during the cell cycle for the successful completion of mitosis, We have cloned a C. elegans homolog of the Drosophila melanogaster polo gene (designated plk-1 for C, elegans polo- like kinase-l) and present the subcellular localization of the PLK-1 protein during the meiotic and mitotic cell cycles in C, elegans oocytes and embryos, respectively. Disruption of PLK-1 expression by RNA-mediated interference (RNAi) disrupts normal oocyte and embryonic development. Inspection of oocytes revealed a defect in nuclear envelope breakdown (NEBD) before ovulation. This defect in NEED was also observed in oocytes that were depleted of the cyclin-dependent kinase NCC-1 (C. elegans homolog of Cdc2), The plk-1 RNAI oocytes were fertilized; however the resulting embryos were unable to separate their meiotic chromosomes or form and extrude polar bodies. These defects led to embryonic arrest as single cells. Published 2000 Wiley-Liss, Inc.(dagger)

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