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The genomic RNA in Ty1 virus-like particles is dimeric

  1. Author:
    Feng, Y. X.
    Moore, S. P.
    Garfinkel, D. J.
    Rein, A.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, HIV Drug Resistance Program, Bldg 535, Room 211, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, HIV Drug Resistance Program, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Gene Regulat & Chromosome Biol Lab, Frederick, MD 21702 USA.
    1. Year: 2000
  2. Journal: Journal of Virology
    1. 74
    2. 22
    3. Pages: 10819-10821
  4. Type of Article: Article
  1. Abstract:

    The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized during the proteolytic maturation of the particle. The statbilization of the dimer suggests that one of the cleavage products of TyA1 possesses nucleic acid chaperone activity.

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