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Cytotoxic Sesquiterpene Coumarins from the Roots of Heptaptera cilicica

  1. Author:
    Tosun, Fatma
    Aytar, Erdi C.
    Beutler,John
    Wilson,Jennifer
    Miski, Mahmut
  2. Author Address

    Istanbul Medipol Univ, Sch Pharm, Dept Pharmacognosy, TR-34810 Istanbul, Turkey.Ondokuz Mayis Univ, Fac Art & Sci, Dept Biol, TR-55200 Samsun, Turkey.NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21702 USA.Istanbul Univ, Fac Pharm, Dept Pharmacognosy, TR-34116 Istanbul, Turkey.
    1. Year: 2021
    2. Date: NOV-DEC
  1. Journal: RECORDS OF NATURAL PRODUCTS
  2. ACG PUBLICATIONS,
    1. 15
    2. 6
    3. Pages: 529-536
  3. Type of Article: Article
  4. ISSN: 1307-6167
  1. Abstract:

    Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent and selective cytotoxic activities were isolated from the dichloromethane extract of the roots of H. cilicica. Furthermore, revised spectroscopic data for 14'-acetoxybadrakemone (4) and complete NMR spectroscopic assignments for colladonin (6) and colladin (7) are reported.

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External Sources

  1. DOI: 10.25135/rnp.242.21.02.1990
  2. WOS: 000658306500009

Library Notes

  1. Fiscal Year: FY2021-2022
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