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The National Cryo-EM Facility at Frederick National Laboratory: Operational Procedures, Methods and Outputs

  1. Author:
    Baxa, Ulrich
    Edwards,Thomas
    Hutchison,Matt
    Wier,Adam
    Finney,Joseph
    Wang,Helen
    Subramaniam, Sriram

  2. Author Address

    Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.,
    1. Year: 2020
    2. Date: May
    3. Epub Date: 2020 05 18
  2. Journal: Microscopy today
    1. 28
    2. 3
    3. Pages: 12-17
  4. Type of Article: Article
  1. Abstract:

    The National Cryo-Electron Microscopy Facility (NCEF) at the National Cancer Institute was launched in May of 2017 to provide free and rapid access to high resolution cryo-EM data collection to United States researchers working on problems of broad general relevance to cancer biology. The decision about suitability of projects for data collection is made on a first-come, first-served basis by NCEF staff, and is based solely on the quality of the screening images provided without need for a scientific proposal. Here, we provide an overview of the operation of the facility, typical data collection procedures and some insights that have emerged from the structures reported from data collected at the facility.

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External Sources

  1. View Full Text
  2. DOI: 10.1017/s1551929520000851
  3. PMID: 34113224
  4. PMCID: PMC8189431

Library Notes

  1. Fiscal Year: FY2020-2021
NCI at Frederick

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