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Consequences of hemophagocytic lymphohistiocytosis-like cytokine release syndrome toxicities and concurrent bacteremia

  1. Author:
    Masih, Katherine E.
    Ligon, John A.
    Yates, Bonnie
    Shalabi, Haneen
    Little, Lauren
    Islam, Zahin
    Ombrello, Amanda K.
    Inglefield,Jon
    Nussenblatt, Veronique
    Manion, Maura
    Khan, Javed
    Shah, Nirali N.

  2. Author Address

    NCI, Oncogen Sect, Genet Branch, Ctr Canc Res CCR,NIH, Bethesda, MD 20892 USA.Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.NCI, Pediat Oncol Branch, CCR, NIH, Bldg 10 Room 1W-3750,9000 Rockville Pike MSC 1104, Bethesda, MD 20892 USA.NHGRI, Inflammatory Dis Sect, NIH, Bethesda, MD 20892 USA.NCI, Appl Dev Res Directorate, Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.NIAID, Infect Dis Consult Serv, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
    1. Year: 2021
    2. Date: Jul 26
    3. Epub Date: 2021 07 26
  2. Journal: Pediatric blood & cancer
  3. WILEY,
  5. Type of Article: Article
  6. Article Number: e29247
  7. ISSN: 1545-5009
  1. Abstract:

    Serious bacterial infections (SBI) can lead to devastating complications with CD19 CAR T cells and cytokine release syndrome (CRS). Little is known about consequences of and risk factors for SBI with novel CAR T-cell constructs or with CRS complicated by HLH-like toxicities. We report on three patients with B-cell acute lymphoblastic leukemia treated with CD22 CAR T cells who developed SBI and CRS-associated HLH. Serum cytokine profiling revealed sustained elevations well beyond CRS resolution, suggesting ongoing systemic inflammation. Heightened inflammatory states converging with SBI contribute to poor outcomes, and recognition and prevention of extended inflammation may be needed to improve outcomes.

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External Sources

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  2. DOI: 10.1002/pbc.29247
  3. PMID: 34309174
  4. View record in Web of Science®
  5. WOS: 000678797300001

Library Notes

  1. Fiscal Year: FY2020-2021
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