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IL-2-induced activation-induced cell death is inhibited in IL- 15 transgenic mice

  1. Author:
    Marks-Konczalik, J.
    Dubois, S.
    Losi, J. M.
    Sabzevari, H.
    Yamada, N.
    Feigenbaum, L.
    Waldmann, T. A.
    Tagaya, Y.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Metab Branch, Div Clin Sci, NIH, Bethesda, MD 20892 USA. NCI, Frederick Canc Res & Dev Ctr, Metab Branch, Div Clin Sci, NIH, Bethesda, MD 20892 USA. NCI, Frederick Canc Res & Dev Ctr, Tumor Immunol & Biol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA. NCI, Frederick Canc Res & Dev Ctr, Dermatol Branch, Div Clin Sci, NIH, Bethesda, MD 20892 USA. NCI, Frederick Canc Res & Dev Ctr, Transgen Mouse Model, Sci Applicat Int Corp Frederick, NIH, Bethesda, MD 20892 USA.
    1. Year: 2000
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 97
    2. 21
    3. Pages: 11445-11450
  4. Type of Article: Article
  1. Abstract:

    A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44(hi)CD8 memory T cells, and gamma delta T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8 alpha alpha' expression. Due to the expansion and activation of NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity, the roles of IL- 15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death, which plays a role in the maintenance of peripheral self-tolerance. IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.

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