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RNA and DNA nanoparticles for triggering RNA interference

  1. Author:
    El Tannir, Ziad
    Afonin, Kirill A
    Shapiro,Bruce

  2. Author Address

    Department of Chemistry, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, North Carolina 28223, USA., Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.,
    1. Year: 2015
    2. Epub Date: 2015 11 29
  2. Journal: RNA & disease (Houston, Tex.)
    1. 2
    2. Suppl 1
  4. Type of Article: Article
  5. Article Number: e724
  1. Abstract:

    Control over the delivery of different functionalities and their synchronized activation in vivo is a challenging undertaking that requires careful design and implementation. The goal of the research highlighted herein was to develop a platform allowing the simultaneous activation of multiple RNA interference pathways and other functionalities inside cells. Our team has developed several RNA, RNA/DNA and DNA/RNA nanoparticles able to successfully complete such tasks. The reported designs can potentially be used to target myriad of different diseases.

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  1. Keywords:

External Sources

  1. PMID: 34307840
  2. PMCID: PMC8301276

Library Notes

  1. Fiscal Year: FY2015-2016
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