Skip NavigationSkip to Content
Return Return to Search Results

Interactions of APOBEC3s with DNA and RNA

  1. Author:
    Maiti, Atanu
    Hou, Shurong
    Schiffer, Celia A.
    Matsuo,Hiroshi

  2. Author Address

    Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21702 USA.Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01655 USA.
    1. Year: 2021
    2. Date: Apr
    3. Epub Date: 2021 01 21
  2. Journal: Current opinion in structural biology
  3. CURRENT BIOLOGY LTD,
    1. 67
    2. Pages: 195-204
  5. Type of Article: Review
  6. ISSN: 0959-440X
  1. Abstract:

    APOBEC3 enzymes are key enzymes in our innate immune system regulating antiviral response in HIV and unfortunately adding diversity in cancer as they deaminate cytosine. Seven unique single and double domain APOBEC3s provide them with unique activity and specificity profiles for this deamination. Recent crystal and NMR structures of APOBEC3 complexes are unraveling the variety of epitopes involved in binding nucleic acids, including at the catalytic site, elsewhere on the catalytic domain and in the inactive N-terminal domain. The interplay between these diverse interactions is critical to uncovering the mechanisms by which APOBEC3s recognize and process their substrates.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.sbi.2020.12.004
  3. PMID: 33486429
  4. View record in Web of Science®
  5. WOS: 000647703900013

Library Notes

  1. Fiscal Year: FY2020-2021
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel