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Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor

  1. Author:
    Park, L. S.
    Martin, U.
    Garka, K.
    Gliniak, B.
    Di Santo, J. P.
    Muller, W.
    Largaespada, D. A.
    Copeland, N. G.
    Jenkins, N. A.
    Farr, A. G.
    Ziegler, S. F.
    Morrissey, P. J.
    Paxton, R.
    Sims, J. E.

  2. Author Address

    Immunex Res & Dev Corp, Dept Biochem, 51 Univ St, Seattle, WA 98101 USA. Immunex Res & Dev Corp, Dept Biochem, Seattle, WA 98101 USA. Immunex Res & Dev Corp, Dept Biol Sci, Seattle, WA 98101 USA. Immunex Res & Dev Corp, Dept Mol Biol, Seattle, WA 98101 USA. Inst Pasteur, Dept Immunol, F-75724 Paris, France. Inst Genet, D-50931 Cologne, Germany. NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab, Frederick, MD 21702 USA. Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA. Virginia Mason Res Ctr, Seattle, WA 98101 USA.
    1. Year: 2000
  2. Journal: Journal of Experimental Medicine
    1. 192
    2. 5
    3. Pages: 659-669
  4. Type of Article: Article
  1. Abstract:

    The,cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell Lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Transfection of TSLPR cDNA resulted in only low affinity binding. Cotransfection of the interleukin 7 (IL-7)R alpha chain cDNA resulted in conversion to high affinity binding. TSLP did not activate cells from IL7R alpha(-/-) mice, but did activate cells h-om gamma c(-/-) mice. Thus, the functional TSLPR requires the IL-7R alpha chain, but not the gamma c chain for signaling.

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