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SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives

  1. Author:
    Long, Samuel

  2. Author Address

    Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD 21702 USA.
    1. Year: 2021
    2. Date: Oct
    3. Epub Date: 2021 09 24
  2. Journal: VIRUSES-BASEL
  3. MDPI,
    1. 13
    2. 10
  5. Type of Article: Review
  6. Article Number: ARTN 1923
  7. ISSN: 1999-4915
  1. Abstract:

    SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed.< /p>

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External Sources

  1. View Full Text
  2. DOI: 10.3390/v13101923
  3. PMID: 34696353
  4. View record in Web of Science®
  5. WOS: 000712305900001

Library Notes

  1. Fiscal Year: FY2021-2022
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