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Molecular cloning and biological characterization of a novel murine lymphoid growth factor

  1. Author:
    Sims, J. E.
    Williams, D. E.
    Morrissey, P. J.
    Garka, K.
    Foxworthe, D.
    Price, V.
    Friend, S. L.
    Farr, A.
    Bedell, M. A.
    Jenkins, N. A.
    Copeland, N. G.
    Grabstein, K.
    Paxton, R. J.

  2. Author Address

    Immunex Res & Dev Corp, Dept Mol Biol, 51 Univ St, Seattle, WA 98101 USA. Immunex Res & Dev Corp, Dept Mol Biol, Seattle, WA 98101 USA. Immunex Res & Dev Corp, Dept Biol Sci, Seattle, WA 98101 USA. Immunex Res & Dev Corp, Dept Prot Chem, Seattle, WA 98101 USA. Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA. NCI, Frederick Canc Res & Dev Ctr, Mammalian Genet Lab, Frederick, MD 21702 USA.
    1. Year: 2000
  2. Journal: Journal of Experimental Medicine
    1. 192
    2. 5
    3. Pages: 671-680
  4. Type of Article: Article
  1. Abstract:

    Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated from a thymic stromal cell line. This factor, termed thymic stromal lymphopoietin (TSLP), isa protein of 140 amino acids. The gene encoding TSLP was mapped to murine chromosome 18. Purified recombinant TSLP supported the growth of pre-B cell colonies in vitro, but had no myelopoietic activity. TSLP had comitogenic activity for fetal thymocytes, but was not as potent as interleukin 7 in lobe submersion cultures. Injection of TSLP into neonatal mice induced the expansion of B220(+)BP-1(+) pre-B cells.

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