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Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

  1. Author:
    King, Hannah A. D.
    Joyce, M. Gordon
    Naouar, Ines Elakhal
    Ahmed, Aslaa
    Cincotta, Camila Macedo
    Subra, Caroline
    Peachman, Kristina K.
    Hack, Holly H.
    Chen, Rita E.
    Thomas, Paul
    Chen, Wei-Hung
    Sankhala, Rajeshwer S.
    Hajduczki, Agnes
    Martinez, Elizabeth J.
    Peterson, Caroline E.
    Chang, William C.
    Choe, Misook
    Smith,Clayton
    Headley, Jarrett A.
    Elyard, Hanne A.
    Cook, Anthony
    Anderson, Alexander
    Wuertz, Kathryn McGuckin
    Dong, Ming
    Swafford, Isabella
    Case, James B.
    Currier, Jeffrey R.
    Lal, Kerri G.
    Amare, Mihret F.
    Dussupt, Vincent
    Molnar, Sebastian
    Daye, Sharon P.
    Zeng, Xiankun
    Barkei, Erica K.
    Alfson, Kendra
    Staples, Hilary M.
    Carrion, Ricardo
    Krebs, Shelly J.
    Paquin-Proulx, Dominic
    Karasavvas, Nicos
    Polonis, Victoria R.
    Jagodzinski, Linda L.
    Vasan, Sandhya
    Scott, Paul T.
    Huang, Yaoxing
    Nair, Manoj S.
    Ho, David D.
    de Val, Natalia
    Diamond, Michael S.
    Lewis, Mark G.
    Rao, Mangala
    Matyas, Gary R.
    Gromowski, Gregory D.
    Peel, Sheila A.
    Michael, Nelson L.
    Modjarrad, Kayvon
    Bolton, Diane L.

  2. Author Address

    Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.Walter Reed Army Inst Res, Emerging Infect Dis Branch, Silver Spring, MD 20910 USA.Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.Walter Reed Army Inst Res, Diagnost & Countermeasures Branch, Silver Spring, MD 20910 USA.Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.Washington Univ, Dept Med, St Louis, MO 63130 USA.Washington Univ, Dept Pathol & Immunol, St Louis, MO 63130 USA.NCI, Ctr Mol Microscopy, Ctr Canc Res, NIH, Frederick, MD 21702 USA.BIOQUAL Inc, Rockville, MD 20850 USA.Walter Reed Army Inst Res, Ctr Infect Dis Res, Silver Spring, MD 20910 USA.US Army Med Res Inst Infect Dis, Div Pathol, Frederick, MD 21702 USA.Walter Reed Army Inst Res, Vet Pathol Branch, Silver Spring, MD 20910 USA.Texas Biomed Res Inst, Dis Intervent & Prevent, San Antonio, TX 78227 USA.Columbia Univ, Aaron Diamond AIDS Res Ctr, Vagelos Coll Phys & Surg, New York, NY 10032 USA.Washington Univ, Dept Mol Microbiol, St Louis, MO 63130 USA.
    1. Year: 2021
    2. Date: SEP 21
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
  3. NATL ACAD SCIENCES,
    1. 118
    2. 38
  5. Type of Article: Article
  6. Article Number: e2106433118
  7. ISSN: 0027-8424
  1. Abstract:

    Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vaccination of macaques using a two-dose regimen resulted in robust, predominantly Th1 CD4+ T cell responses and reciprocal peak mean serum neutralizing antibody titers of 14,000 to 21,000. Rapid control of viral replication was achieved in the upper and lower airways of animals after high-dose SARS-CoV-2 respiratory challenge, with undetectable replication within 4 d in seven of eight animals receiving 50 mu g of RFN. Cross-neutralization activity against SARS-CoV-2 variant B.1.351 decreased only approximately twofold relative to WA1/2020. In addition, neutralizing, effector antibody and cellular responses targeted the heterotypic SARS-CoV-1, highlighting the broad immunogenicity of RFN-ALFQ for SARS-CoV-like Sarbecovirus vaccine development.

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External Sources

  1. View Full Text
  2. DOI: 10.1073/pnas.2106433118
  3. PMID: 34470866
  4. PMCID: PMC8463842
  5. View record in Web of Science®
  6. WOS: 000704002000013

Library Notes

  1. Fiscal Year: FY2021-2022
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