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The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities

  1. Author:
    Vujkovic-Cvijin, Ivan
    Sortino,Ornella
    Verheij, Eveline
    Wit, Ferdinand W.
    Kootstra, Neeltje A.
    Sellers, Brian
    van der Loeff, Maarten Schim
    Belkaid, Yasmine
    Reiss, Peter
    Sereti, Irini

  2. Author Address

    NIAID, Metaorganism Immun Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.NCI, Clin Monitoring Res Program Directorate, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Global Hlth, Amsterdam, Netherlands.Amsterdam Publ Hlth Res Inst, Amsterdam Infect & Immun Inst, Div Infect Dis, Amsterdam, Netherlands.Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands.Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Infect & Immun Inst, Dept Expt Immunol, Amsterdam, Netherlands.NIH, Trans NIH Ctr Human Immunol Autoimmun & Inflammat, Bldg 10, Bethesda, MD 20892 USA.Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.
    1. Year: 2021
    2. Date: Oct 28
  2. Journal: Journal of Infectious Diseases
  3. Oxford University Press
    1. 224
    2. 8
    3. Pages: 1405-1409
  5. Type of Article: Article
  6. ISSN: 0022-1899
  1. Abstract:

    Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiab096
  3. PMID: 33606018
  4. View record in Web of Science®
  5. WOS: 000715883900017

Library Notes

  1. Fiscal Year: FY2021-2022
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