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The metabolic landscape of RAS-driven cancers from biology to therapy

  1. Author:
    Mukhopadhyay,Suman
    Vander Heiden, Matthew G.
    McCormick, Frank

  2. Author Address

    Frederick Natl Lab Canc Res, Canc Res Technol Program, Natl Canc Inst RAS Initiat, Frederick, MD 21701 USA.MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.MIT, Dept Biol, Cambridge, MA USA.Dana Farber Canc Inst, Boston, MA 02115 USA.Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA.NYU, Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA.
    1. Year: 2021
    2. Date: Mar
    3. Epub Date: 2021 Mar 24
  2. Journal: Nature Cancer
  3. SpringerNature
    1. 2
    2. 3
    3. Pages: 271-283
  5. Type of Article: Article
  6. ISSN: 2662-1347
  1. Abstract:

    Our understanding of how the RAS protein family, and in particular mutant KRAS, promotes metabolic dysregulation in cancer cells has advanced substantially over the last decade. In this Review, we discuss the metabolic reprogramming mediated by oncogenic RAS in cancer and elucidate the underlying mechanisms that could translate to novel therapeutic opportunities to target metabolic vulnerabilities in RAS-driven cancers.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s43018-021-00184-x
  3. PMID: 33870211
  4. PMCID: PMC8045781
  5. View record in Web of Science®
  6. WOS: 000634948000006

Library Notes

  1. Fiscal Year: FY2020-2021
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