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Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors

  1. Author:
    Phelps, Tim E.
    Roy, Jyoti
    Green, Michael V.
    Seidel,Jurgen
    Baidoo, Kwamena E.
    Adler,Stephen
    Edmondson,Elijah
    Butcher,Donna
    Matta,Jennifer
    Ton, Anita T.
    Wong, Karen
    Huang, Shan
    Ren, Ling
    LeBlanc, Amy K.
    Choyke, Peter L.
    Jagoda, Elaine M.

  2. Author Address

    NCI, Mol Imaging Branch, NIH, 10 Ctr Dr,Bldg 10-B3B69, Bethesda, MD 20892 USA.NCI, Clin Res Directorate, Frederick Natl Lab Canc Res, Bethesda, MD 20892 USA.NCI, Mol Histopathol Lab, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.
    1. Year: 2021
    2. Date: Mar
    3. Epub Date: 2021 02 25
  2. Journal: Cancer biotherapy & radiopharmaceuticals
  3. MARY ANN LIEBERT, INC,
    1. 36
    2. 2
    3. Pages: 133-142
  5. Type of Article: Article
  6. ISSN: 1084-9785
  1. Abstract:

    Background: Patients with osteoblastic bone metastases are candidates for radium-223 ((RaCl2)-Ra-223) therapy and may undergo sodium fluoride-18 (F-18-NaF) positron emission tomography-computed tomography imaging to identify bone lesions. F-18-NaF has been shown to predict (RaCl2)-Ra-223 uptake, but intratumor distributions of these two agents remain unclear. In this study, the authors evaluate the spatial distribution and relative uptakes of F-18-NaF and (RaCl2)-Ra-223 in Hu09-H3 human osteosarcoma mouse xenograft tumors at macroscopic and microscopic levels to better quantify their correlation.

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External Sources

  1. View Full Text
  2. DOI: 10.1089/cbr.2020.4068
  3. PMID: 33646017
  4. PMCID: PMC7994428
  5. View record in Web of Science®
  6. WOS: 000624607900001

Library Notes

  1. Fiscal Year: FY2020-2021
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