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My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype

  1. Author:
    Zhou, Yadi
    Zhao, Junfei
    Fang, Jiansong
    Martin, William
    Li, Lang
    Nussinov,Ruth
    Chan, Timothy A.
    Eng, Charis
    Cheng, Feixiong

  2. Author Address

    Cleveland Clin, Lerner Res Inst, Genom Med Inst, Cleveland, OH 44195 USA.Columbia Univ, Herbert Irving Comprehens Ctr, Dept Syst Biol, New York, NY 10032 USA.Columbia Univ, Dept Biomed Informat, New York, NY 10032 USA.Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA.Natl Canc Inst Frederick, Frederick Natl Lab Canc Res, Computat Struct Biol Sect, Basic Sci Program, Frederick, MD 21702 USA.Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, IL-69978 Tel Aviv, Israel.Cleveland Clin, Lerner Res Inst, Ctr Immunotherapy & Precis Immunooncol, Cleveland, OH 44195 USA.Case Western Reserve Univ, Coll Med, Cleveland Clin Lerner, Dept Mol Med, Cleveland, OH 44195 USA.Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA.Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44195 USA.Case Western Reserve Univ, Sch Med, Dept Genet & Genome Sci, Cleveland, OH 44106 USA.
    1. Year: 2021
    2. Date: Jan 29
  2. Journal: Genome Biology
  3. BMC,
    1. 22
    2. 1
  5. Type of Article: Article
  6. Article Number: 53
  7. ISSN: 1474-760X
  1. Abstract:

    Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols. MPM contains 490,245 mutations from over 10,800 tumor exomes across 33 cancer types in The Cancer Genome Atlas mapped to 94,563 structure-resolved/predicted protein-protein interaction interfaces ("edgetic") and 311,022 functional sites ("nodetic"), including ligand-protein binding sites and 8 types of protein posttranslational modifications. In total, 8884 survival results and 1,271,132 drug responses are obtained for these mapped interactions. MPM is available at https://mutanome.lerner.ccf.org.

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External Sources

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  2. DOI: 10.1186/s13059-021-02269-3
  3. PMID: 33514395
  4. PMCID: PMC7845113
  5. View record in Web of Science®
  6. WOS: 000616421900002

Library Notes

  1. Fiscal Year: FY2020-2021
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