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Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

  1. Author:
    Woo, Xing Yi
    Giordano, Jessica
    Srivastava, Anuj
    Zhao, Zi-Ming
    Lloyd, Michael W.
    de Bruijn, Roebi
    Suh, Yun-Suhk
    Patidar, Rajesh
    Chen,Li
    Scherer, Sandra
    Bailey, Matthew H.
    Yang, Chieh-Hsiang
    Cortes-Sanchez, Emilio
    Xi, Yuanxin
    Wang, Jing
    Wickramasinghe, Jayamanna
    Kossenkov, Andrew V.
    Rebecca, Vito W.
    Sun, Hua
    Mashl, R. Jay
    Davies, Sherri R.
    Jeon, Ryan
    Frech, Christian
    Randjelovic, Jelena
    Rosains, Jacqueline
    Galimi, Francesco
    Bertotti, Andrea
    Lafferty, Adam
    O'Farrell, Alice C.
    Modave, Elodie
    Lambrechts, Diether
    ter Brugge, Petra
    Serra, Violeta
    Marangoni, Elisabetta
    El Botty, Rania
    Kim, Hyunsoo
    Kim, Jong-Il
    Yang, Han-Kwang
    Lee, Charles
    Dean, Dennis A.
    Davis-Dusenbery, Brandi
    Evrard, Yvonne A.
    Doroshow, James H.
    Welm, Alana L.
    Welm, Bryan E.
    Lewis, Michael T.
    Fang, Bingliang
    Roth, Jack A.
    Meric-Bernstam, Funda
    Herlyn, Meenhard
    Davies, Michael A.
    Ding, Li
    Li, Shunqiang
    Govindan, Ramaswamy
    Isella, Claudio
    Moscow, Jeffrey A.
    Trusolino, Livio
    Byrne, Annette T.
    Jonkers, Jos
    Bult, Carol J.
    Medico, Enzo
    Chuang, Jeffrey H.

  2. Author Address

    Jackson Lab Genom Med, Farmington, CT 06032 USA.Univ Turin, Dept Oncol, Turin, Italy.IRCCS, FPO, Candiolo Canc Inst, Turin, Italy.Jackson Lab Mammalian Genet, Bar Harbor, ME USA.Netherlands Canc Inst, Amsterdam, Netherlands.Seoul Natl Univ, Coll Med, Seoul, South Korea.Frederick Natl Lab Canc Res, Frederick, MD USA.Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT USA.Univ Utah, Dept Human Genet, Salt Lake City, UT USA.Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA.Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.Seven Bridges Genom, Charlestown, MA USA.Royal Coll Surgeons Ireland, Ctr Syst Med, Dept Physiol & Med Phys, Dublin, Ireland.VIB, Ctr Canc Biol, Leuven, Belgium.Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium.Vall dHebron Inst Oncol, Barcelona, Spain.PSL Res Univ, Inst Curie, Dept Translat Res, Paris, France.Xi An Jiao Tong Univ, Affiliated Hosp 1, Precis Med Ctr, Xian, Peoples R China.Ewha Womans Univ, Dept Life Sci, Seoul, South Korea.NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.Univ Utah, Dept Surg, Huntsman Canc Inst, Salt Lake City, UT USA.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA.Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA.Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA.Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA.NCI, Invest Drug Branch, Bethesda, MD 20892 USA.
    1. Year: 2021
    2. Date: Jan
    3. Epub Date: 2021 Jan 07
  2. Journal: Nature Genetics
  3. NATURE RESEARCH,
    1. 53
    2. 1
    3. Pages: 86-99
  5. Type of Article: Article
  6. ISSN: 1061-4036
  1. Abstract:

    Analysis of copy number alterations in 1,451 patient-derived xenografts (PDXs) and matched patient tumor samples shows strong conservation from patient tumors through late-passage PDXs and a lack of systematic copy number evolution driven by the mouse host.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41588-020-00750-6
  3. PMID: 33414553
  4. PMCID: PMC7808565
  5. View record in Web of Science®
  6. WOS: 000605984400012

Library Notes

  1. Fiscal Year: FY2020-2021
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