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Novel cytotoxic diterpenes from Casearia arborea

  1. Author:
    Beutler, J. A.
    McCall, K. L.
    Herbert, K.
    Herald, D. L.
    Pettit, G. R.
    Johnson, T.
    Shoemaker, R. H.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De Bldg 1052,Rm 121 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Journal of Natural Products
    1. 63
    2. 5
    3. Pages: 657-661
  4. Type of Article: Article
  1. Abstract:

    Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography. [References: 21]

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  2. DOI: 10.1021/np990553r
  3. PMID: 10843580

Library Notes

  1. Student Author
NCI at Frederick

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