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Polyfunctional antigen specific CD4± T cell responses in Patients with HIV/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

  1. Author:
    Manion, Maura [ORCID]
    Boulougoura, Afroditi
    Naqvi, Nuha
    Lage, Silvia Lucena
    Richards, Elizabeth
    Grivas, Christopher
    Laidlaw, Elizabeth
    Kuriakose, Safia
    Ortega-Villa, Ana M
    Tadros, Saber
    Roby, Gregg
    Rupert,Adam
    Galindo, France
    Anderson, Megan
    Pau, Alice
    Deepe, George
    Sheikh, Virginia
    Sereti, Irini

  2. Author Address

    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States., Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Bethesda, Maryland, United States., National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States., Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland,United States., Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States.,
    1. Year: 2022
    2. Date: Jun 29
    3. Epub Date: 2022 06 29
  2. Journal: Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America
  4. Type of Article: Article
  1. Abstract:

    In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with HIV. We immunologically characterized ten cases of histoplasmosis, four of whom developed histoplasmosis IRIS. CD4+ T-cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen. © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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External Sources

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  2. DOI: 10.1093/cid/ciac514
  3. PMID: 35767272
  4. PII : 6619620

Library Notes

  1. Fiscal Year: FY2021-2022
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