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Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells

  1. Author:
    Kim, Sang Hoon [ORCID]
    Song, Jae Ho
    Kim, Min Ji
    Song, Mun Gu
    Ku, Angel A [ORCID]
    Bandyopadhyay, Sourav
    McCormick, Frank
    Kim, Sung Eun [ORCID]

  2. Author Address

    Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea., Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea., Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA., Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.,
    1. Year: 2022
    2. Date: Sep 02
    3. Epub Date: 2022 09 02
  2. Journal: Metabolites
    1. 12
    2. 9
  4. Type of Article: Article
  5. Article Number: 831
  1. Abstract:

    Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS signaling, such as pancreatic cancer. However, the absence of a clinically available inhibitor, as well as the gap of knowledge in macropinocytosis regulation, remain a hurdle for its use for cancer therapy. Here, we use the Informer set library to identify novel regulators of macropinocytosis-dependent growth in pancreatic cancer cells. Understanding how these regulators function will allow us to provide novel opportunities for therapeutic intervention.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/metabo12090831
  3. PMID: 36144235
  4. PMCID: PMC9502772
  5. PII : metabo12090831

Library Notes

  1. Fiscal Year: FY2022-2023
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