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Ly49 gene expression in different inbred mouse strains

  1. Author:
    Makrigiannis, A. P.
    Anderson, S. K.

  2. Author Address

    Anderson SK NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Intramural Res Support Program Bldg 560,Rm 31-93 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Intramural Res Support Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Expt Immunol Lab, Div Basic Sci Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Immunologic Research
    1. 21
    2. 1
    3. Pages: 39-47
  4. Type of Article: Article
  1. Abstract:

    Mouse natural killer cells express receptors for class I MHC in the form of the Ly49 family of proteins. The Ly49 family contains at least 13 expressed members (A, B, C, D, E, F, G, H, I, J, L, O, and P) and is further subdivided into activating and inhibitory subfamilies based on intracellular and transmembrane characteristics. The level of sequence identity between different members varies dramatically. However, comparison of the extracellular domain has revealed that several of the Ly49 molecules also form "pairs," where one member is activating and the other is inhibitory. Until recently, most Ly49 molecules described have come from the C57B1/6 strain of inbred mice. Using molecular cloning and immunochemical analysis we have found that different mouse strains express novel Ly49 molecules. Comparison of the allelic forms of some Ly49 molecules has shown that the dividing line between different genes and different alleles is blurred. [References: 28]

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