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Multi-scale signaling and tumor evolution in high-grade gliomas

  1. Author:
    Liu, Jingxian
    Cao, Song
    Imbach, Kathleen J
    Gritsenko, Marina A
    Lih, Tung-Shing M
    Kyle, Jennifer E
    Yaron-Barir, Tomer M
    Binder, Zev A
    Li, Yize
    Strunilin, Ilya
    Wang, Yi-Ting
    Tsai, Chia-Feng
    Ma, Weiping
    Chen, Lijun
    Clark, Natalie M
    Shinkle, Andrew
    Naser Al Deen, Nataly
    Caravan, Wagma
    Houston, Andrew
    Simin, Faria Anjum
    Wyczalkowski, Matthew A
    Wang, Liang-Bo
    Storrs, Erik
    Chen, Siqi
    Illindala, Ritvik
    Li, Yuping D
    Jayasinghe, Reyka G
    Rykunov, Dmitry
    Cottingham, Sandra L
    Chu, Rosalie K
    Weitz, Karl K
    Moore, Ronald J
    Sagendorf, Tyler
    Petyuk, Vladislav A
    Nestor, Michael
    Bramer, Lisa M
    Stratton, Kelly G
    Schepmoes, Athena A
    Couvillion, Sneha P
    Eder, Josie
    Kim, Young-Mo
    Gao, Yuqian
    Fillmore, Thomas L
    Zhao, Rui
    Monroe, Matthew E
    Southard-Smith, Austin N
    Li, Yang E
    Jui-Hsien Lu, Rita
    Johnson, Jared L
    Wiznerowicz, Maciej
    Hostetter, Galen
    Newton, Chelsea J
    Ketchum, Karen A
    Thangudu, Ratna R
    Barnholtz-Sloan, Jill S
    Wang, Pei
    Fenyö, David
    An, Eunkyung
    Thiagarajan,Mathangi
    Robles, Ana I
    Mani, D R
    Smith, Richard D
    Porta-Pardo, Eduard
    Cantley, Lewis C
    Iavarone, Antonio
    Chen, Feng
    Mesri, Mehdi
    Nasrallah, MacLean P
    Zhang, Hui
    Resnick, Adam C
    Chheda, Milan G
    Rodland, Karin D
    Liu, Tao
    Ding, Li

  2. Author Address

    Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA., Josep Carreras Leukaemia Research Institute, Badalona, Spain; Universidad Aut 243;noma de Barcelona, 08193 Bellaterra, Barcelona, Spain., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63130, USA., Department of Pathology, Spectrum Health and Helen DeVos Children 39;s Hospital, Grand Rapids, MI, USA., Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA., International Institute for Molecular Oncology, Poznan, Poland; Poznan University of Medical Sciences, Poznan, Poland., Van Andel Research Institute, Grand Rapids, MI, USA., ICF, 530 Gaither Road Suite 500 Rockville, MD 20850, USA., Center for Biomedical Informatics and Information Technology & Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20850, USA., Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Frederick National Laboratory for Cancer Research, Frederick MD 21701, USA., Josep Carreras Leukaemia Research Institute, Badalona, Spain., Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Department of Neurological Surgery and Department of Biochemistry, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63130, USA., Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Center for Data Driven Discovery in Biomedicine, The Children 39;s Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Neurosurgery, The Children 39;s Hospital of Philadelphia, Philadelphia, PA 19104, USA., Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: mchheda@wustl.edu., Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97221, USA. Electronic address: rodland@ohsu.edu., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA. Electronic address: tao.liu@pnnl.gov., Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: lding@wustl.edu.,
    1. Year: 2024
    2. Date: Jul 08
  2. Journal: Cancer Cell
    1. 42
    2. 7
    3. Pages: 1217-1238.e19
  4. Type of Article: Article
  1. Abstract:

    Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and evolution. Applying 14 proteogenomic and metabolomic platforms to 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators, reveals heterogeneous upstream alterations converging on common downstream events at the proteomic and metabolomic levels and changes in protein-protein interactions and glycosylation site occupancy at recurrence. Recurrent genetic alterations and phosphorylation events on PTPN11 map to important regulatory domains in three dimensions, suggesting a central role for PTPN11 signaling across high-grade gliomas. Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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  2. DOI: 10.1016/j.ccell.2024.06.004
  3. PMID: 38981438
  4. PII : S1535-6108(24)00229-0

Library Notes

  1. Fiscal Year: FY2023-2024
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