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Focusing on antimicrobial resistant infections -are we missing the forest for the trees and the patients for pathogens?

  1. Author:
    Lawandi, Alexander
    Kadri, Sameer S
    Powers,John

  2. Author Address

    Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, United States., Division of Infectious Diseases, Department of Medicine, McGill University Health Center, Montreal, QC, Canada., Division of Medical Microbiology, Department of Laboratory Medicine, McGill University Health Centre, Montreal, QC, Canada., Department of Critical Care Medicine, McGill University Health Centre, Montreal, QC, Canada., Critical Care Medicine Branch, National Heart, Lung, Blood Institute, Bethesda, MD, United States., Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.,
    1. Year: 2023
    2. Epub Date: 2023 12 19
  2. Journal: Frontiers in Antibiotics
    1. 2
    2. Pages: 1329081
  4. Type of Article: Article
  5. Article Number: 1329081
  1. Abstract:

    Antimicrobial resistance (AMR) is a challenge because it is associated with worse patient outcomes. To solve the problem will take development of interventions and policies which improve patient outcomes by prolonging survival, improving patient symptoms, function and quality of life. Logically, we should look to focusing resources in areas that would have the greatest impact on public health. AMR takes the approach of focusing on individual pathogens and "pathogen-focused" development. However, evaluating overall infections and their impact on patient outcomes reveals that 17 of 18 infection deaths are associated with susceptible pathogens. Here we discuss recentering on patients and patient outcomes instead of pathogens, and propose six suggestions on how a patient focus impacts areas and incentives for clinical research. Copyright © 2023 Lawandi, Kadri and Powers.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/frabi.2023.1329081
  3. PMID: 39816657
  4. PMCID: PMC11731989

Library Notes

  1. Fiscal Year: FY2024-2025
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