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Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen

  1. Author:
    de Quiros, J.
    Shupert, W. L.
    McNeil, A. C.
    Gea-Banacloche, J. C.
    Flanigan, M.
    Savage, A.
    Martino, L.
    Weiskopf, E. E.
    Imamichi, H.
    Zhang, Y. M.
    Adelsburger, J.
    Stevens, R.
    Murphy, P. M.
    Zimmerman, P. A.
    Hallahan, C. W.
    Davey, R. T.
    Connors, M.

  2. Author Address

    Connors M NIAID, Immunoregulat Lab, NIH Bldg 10,Room 11B-09,10 Ctr Dr,MSC 1876 Bethesda, MD 20892 USA NIAID, Immunoregulat Lab, NIH Bethesda, MD 20892 USA NIAID, Host Def Lab, NIH Bethesda, MD 20892 USA Univ Autonoma Madrid, Clin Puerta Hierro, Serv Med Interna 1 Madrid Spain Hosp Gen Gregorio Maranon, Microbiol Serv Madrid Spain NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick Frederick, MD USA
    1. Year: 2000
  2. Journal: Journal of Virology
    1. 74
    2. 4
    3. Pages: 2023-2028
  4. Type of Article: Article
  1. Abstract:

    High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen. [References: 37]

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