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Photo-crosslinkers boost structural information from crosslinking mass spectrometry

  1. Author:
    Ciancone, Anthony
    O'Reilly, Francis J

  2. Author Address

    Center for Structural Biology, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD 21702-1201, USA., Center for Structural Biology, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD 21702-1201, USA. Electronic address: oreillyfj@nih.gov.,
    1. Year: 2025
    2. Date: Jul 04
    3. Epub Date: 2025 07 04
  2. Journal: Current Opinion in Structural Biology
    1. 93
    2. Pages: 103102
  4. Type of Article: Review
  5. Article Number: 103102
  1. Abstract:

    Crosslinking mass spectrometry has emerged as a powerful tool in structural biology. This technology utilizes chemical crosslinkers to capture spatial proximities between protein residues to probe the organization, stoichiometry, and flexibility of protein assemblies under near-native conditions. Photo-crosslinking reagents have become increasingly used in crosslinking MS, with chemical properties that offer significant advantages when studying dynamic protein structures. This review explores the fundamentals, applications, and future potential of photo-crosslinkers in crosslinking mass spectrometry. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.sbi.2025.103102
  3. PMID: 40616977

Library Notes

  1. Fiscal Year: FY2024-2025
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