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A functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONEI using a monochromosome transfer approach

  1. Author:
    Cheng, Y.
    Stanbridge, E. J.
    Kong, H.
    Bengtsson, U.
    Lerman, M. I.
    Lung, M. L.

  2. Author Address

    Lung ML Hong Kong Univ Sci & Technol, Dept Biol Clear Water Bay Kowloon Hong Kong Peoples R China Hong Kong Univ Sci & Technol, Dept Biol Kowloon Hong Kong Peoples R China Univ Calif Irvine, Dept Microbiol & Mol Genet Irvine, CA 92717 USA NCI Frederick, MD 21701 USA
    1. Year: 2000
  2. Journal: Genes Chromosomes & Cancer
    1. 28
    2. 1
    3. Pages: 82-91
  4. Type of Article: Article
  1. Abstract:

    Monochromosome transfers of selected chromosomes into a nasopharyngeal carcinoma (NPC) cell line were performed to determine if tumor suppressing activity for NPC mapped to chromosomes 9, 11, and 17. Current information from cytogenetic and molecular allelotyping studies indicate that these chromosomes may harbor potential tumor suppressor genes vital to NPC. The present results shaw the importance of CDKN2A on chromosome 9 in NPC development. There was no functional suppression of tumor development in nude mice with microcell hybrids harboring the newly transferred chromosome 9 containing an interstitial deletion at 9p21, whereas transfection of CDKN2A into the NPC HONEI cells resulted in obvious growth suppression. Whereas intact chromosome 17 transfers into HONEI cells showed no functional suppression of tumor formation, chromosome 11 was able to do so. Molecular analysis of chromosome 11 tumor segregants indicated that at least two tumor suppressive regions mapping to 11q13 and 11q22-23 may be critical for the development of NPC. Genes Chromosomes Cancer 28:82-41, 2000. (C) 2000 Wiley-Liss, Inc. [References: 49]

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