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Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

  1. Author:
    Yabuta, N.
    Fujii, T.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Nishiguchi, H.
    Endo, Y.
    Toji, S.
    Tanaka, H.
    Nishimune, Y.
    Nojima, H.

  2. Author Address

    Nojima H Osaka Univ, Dept Mol Genet 3-1 Yamadaoka Suita Osaka 5650871 Japan Osaka Univ, Dept Mol Genet Suita Osaka 5650871 Japan Osaka Univ, Dept Sci Lab Anim Expt, Microbial Dis Res Inst Suita Osaka 5650871 Japan NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA Toyobo Co Ltd, Tsuruga Inst Biotechnol Tsuruga 9140047 Japan Fukushima Med Coll, Dept Biochem Fukushima 9601247 Japan MBL Co Ltd, Ina Labs Nagano 3960002 Japan
    1. Year: 2000
  2. Journal: Genomics
    1. 63
    2. 2
    3. Pages: 263-270
  4. Type of Article: Article
  1. Abstract:

    We have cloned and characterized LATS2, a novel mammalian homologue of the Drosophila tumor suppressor gene lats/warts, Northern blot analysis showed ubiquitous expression of mouse LATS2 (MmLATS2) mRNA, whereas expression of human LATS2 (HsLATS2) mRNA was enhanced in skeletal muscle and heart. Immunoblotting analysis of fractionated cell lysates showed HsLats2 to be a nuclear protein, We mapped the MmLATS2 gene to mouse chromosome 14 by interspecific backcross analysis. We also mapped the HsLATS2 gene (by fluorescence in situ hybridization) to the 13q11-q12 region, in which a loss of heterozygosity has been frequently observed in many primary cancers and to which the tumor suppressor genes RE and BRCA2 have also been mapped. (C) 2000 Academic Press. [References: 23]

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