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Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice

  1. Author:
    Liebl, D. J.
    Klesse, L. J.
    Tessarollo, L.
    Wohlman, T.
    Parada, L. F.

  2. Author Address

    Parada LF Univ Texas, SW Med Ctr, Ctr Dev Biol 6000 Harry Hines Blvd Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Ctr Dev Biol Dallas, TX 75235 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Neural Dev Grp Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 97
    2. 5
    3. Pages: 2297-2302
  4. Type of Article: Article
  1. Abstract:

    Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports survival of neurons that differentiate primarily into proprioceptors whereas nerve growth factor and brain-derived neurotrophic factor (BDNF) support subpopulations that transmit nociception and mechanoreception, respectively. We examined sensory neurons of gene-targeted mouse mutants at the NT-4, BDNF, NT-3, and TrkA loci. We show that NT-4 functions early in gangliogenesis, upstream of BDNF. In the absence of NT-4 function, BDNF-dependent, TrkB-expressing neurons fail to appear. The results are consistent with the model that precursor cells intended to become BDNF-dependent mechanoreceptors instead differentiate into NT-3-dependent proprioceptive neurons. [References: 44]

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