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Anti-apoptotic action of macrophage stimulating protein (MSP)

  1. Author:
    Danilkovitch-Miagkova, A.
    Leonard, E. J.

  2. Author Address

    NCI, Immunopathol Sect, Immunobiol Lab, Bldg 560, Room 1246, Frederick, MD 21702 USA. NCI, Immunopathol Sect, Immunobiol Lab, Frederick, MD 21702 USA. Danilkovitch-Miagkova A NCI, Immunopathol Sect, Immunobiol Lab, Bldg 560, Room 1246, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Apoptosis
    1. 6
    2. 3
    3. Pages: 183-190
  4. Type of Article: Article
  1. Abstract:

    MSP is a serum protein belonging to the plasminogen-related kringle domain protein family. In addition to macrophages, epithelial cells are also MSP targets. MSP is a multifunctional factor regulating cell adhesion and motility, growth and survival. MSP mediates its biological activities by activating a transmembrane receptor tyrosine kinase called RON in humans or SKT in mice. MSP can protect epithelial cells from apoptosis by activating two independent signals in the PI3-K/AKT or the MAPK pathway. The MAPK pathway mediates the MSP anti-apoptotic effect only if additional signaling pathways are activated through adhesion. This indicates that MSP receptors and integrins, the receptors mediating cell-matrix-dependent adhesion, can collaborate in promotion of cell survival. This adhesion-dependent pathway, which is essential for the MAPK- mediated anti-apoptotic effect, remains to be identified. A hypothesis that Stat3 might represent a key component of the adhesion-induced anti-apoptotic pathway is presented in this review.

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