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Proliferation, cell cycle and apoptosis in cancer

  1. Author:
    Evan, G. I.
    Vousden, K. H.

  2. Author Address

    Univ Calif San Francisco, Ctr Canc, 2340 Sutter St, San Francisco, CA 94143 USA. Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA. NCI, Frederick, MD 20842 USA. Evan GI Univ Calif San Francisco, Ctr Canc, 2340 Sutter St, San Francisco, CA 94143 USA.
    1. Year: 2001
  2. Journal: Nature
    1. 411
    2. 6835
    3. Pages: 342-348
  4. Type of Article: Article
  1. Abstract:

    Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.

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