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Recombinant hepatitis E virus genomes infectious for primates: Importance of capping and discovery of a cis-reactive element

  1. Author:
    Emerson, S. U.
    Zhang, M.
    Meng, X. J.
    Nguyen, H.
    St Claire, M.
    Govindarajan, S.
    Huang, Y. K.
    Purcell, R. H.

  2. Author Address

    NIAID, Mol Hepatitis & Hepatitis Viruses Sect, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. NIAID, Mol Hepatitis & Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. Bioqual Inc, Rockville, MD 20850 USA. Rancho Los Amigos Med Ctr, Liver Res & Educ Fdn, Downey, CA 90242 USA. NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA. Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Ctr Mol Med & Infect Dis, Blacksburg, VA 20461 USA. NCI, Canc Res Ctr, Frederick, MD 21702 USA. Emerson SU NIAID, Mol Hepatitis & Hepatitis Viruses Sect, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 98
    2. 26
    3. Pages: 15270-15275
  4. Type of Article: Article
  1. Abstract:

    Hepatitis E virus recombinant genomes transcribed in vitro from two cDNA clones differing by two nucleotides were infectious for chimpanzees. However, one cDNA clone encoded a virus that was attenuated for chimpanzees and unable to infect rhesus monkeys. The second cDNA clone encoded a virus that infected both chimpanzees and rhesus monkeys and caused acute hepatitis in both. One mutation differentiating the two clones identified a cis-reactive element that appeared to overlap the 3' end of the capsid gene and part of the 3' noncoding region. Capping of the RNA transcripts was essential for infectivity.

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