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Polymorphisms in inflammatory cytokines and Fc gamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study

  1. Author:
    Foster, C. B.
    Zhu, S. X.
    Erichsen, H. C.
    Lehrnbecher, T.
    Hart, E. S.
    Choi, E.
    Stein, S.
    Smith, M. W.
    Steinberg, S. M.
    Imbach, P.
    Kuhne, T.
    Chanock, S. J.

  2. Author Address

    NCI, Ctr Adv Technol, Pediat Oncol Branch, Immunocompromised Host Sect, NIH, 8717 Grovemont Circle, Gaithersburg, MD 20877 USA. NCI, Ctr Adv Technol, Pediat Oncol Branch, Immunocompromised Host Sect, NIH, Gaithersburg, MD 20877 USA. NCI, Sci Applicat Int Corp, Frederick, MD 21701 USA. NCI, Biostat & Data Management Sect, NIH, Bethesda, MD 20892 USA. Univ Basel, Basel, Switzerland. Chanock SJ NCI, Ctr Adv Technol, Pediat Oncol Branch, Immunocompromised Host Sect, NIH, 8717 Grovemont Circle, Gaithersburg, MD 20877 USA.
    1. Year: 2001
  2. Journal: British Journal of Haematology
    1. 113
    2. 3
    3. Pages: 596-599
  4. Type of Article: Article
  1. Abstract:

    Inflammatory cytokines and low-affinity Fc gamma receptor (Fc gammaR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity Fc gamma Rs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP, These results provide preliminary evidence that variant genotypes of Fc gamma Rs and cytokines contribute to cITP pathogenesis.

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